| Samanv | One who brings things together. |
| Samoa | Sacred center of the universe. |
| Samwell | God has heard the prayer. |
| Sanchar | Movement or transmission. |
| Sancus | Ancient Roman god of trust. |
| Sankho | A sacred conch shell symbol. |
| Sano | A name meaning healthy one. |
| Saranyu | A Hindu goddess of the clouds. |
| Sarpa | A Sanskrit word meaning a serpent. |
| Savitr | A solar deity of the Vedic religion. |
| Savoie | Derived from the Latin word sapaudia. |
| Savu | A Finnish name meaning wise. |
| Savyas | One who is very skillful. |
| Saw | A name meaning to perceive. |
| Scale | A name meaning to climb up. |
| Schwartz | A name meaning dark color. |
| Screech | A name meaning sharp sound. |
| Script | A name meaning written text. |
| Sebek | An ancient Egyptian god. |
| Sekh | Ancient Egyptian for power. |
| Sekhem | Egyptian term for life force. |
| Seno | A name meaning gift of God. |
| Sentry | A soldier stationed to keep a guard. |
| Seo | A Korean name meaning auspicious omen. |
| Septon | A religious leader in fantasy fiction. |
| Seram | Named after an island in Indonesia. |
| Server | A computer providing network services. |
| Servo | A device for precise motion control. |
| Setesh | Ancient Egyptian god of the desert. |
| Seti | Name meaning of the god of the desert. |
| Shadja | The first note in Indian classical music. |
| Shaileshwar | Lord of the mountains, Lord Shiva. |
| Shaktimaan | Possessing great inner power |
| Shakuntav | Related to a sacred bird |
| Shank | A sacred conch shell |
| Shard | A small broken fragment |
| Sharp | Having a keen cutting edge |
| Shat | Representing the number hundred |
| Shatru | An adversary or an enemy |
| Shemsu | A loyal follower or servant. |